منابع مشابه
Iron alters red blood cell morphology.
Under physiologic conditions a small percentage ( 3%) of red blood cells (RBCs) are irreversibly trapped within the fibrin clot mesh. By contrast, in prothrombotic states such as diabetes mellitus, significantly more RBCs are tightly bound to fibrin fibers. Such interactions affect clot properties, making it more resistant to fibrinolytic degradation. This phenomenon may explain thrombolytic re...
متن کاملTestosterone alters iron metabolism and stimulates red blood cell production independently of dihydrotestosterone.
Testosterone (T) stimulates erythropoiesis and regulates iron homeostasis. However, it remains unknown whether the (type II) 5α-reduction of T to dihydrotestosterone (DHT) mediates these androgenic effects, as it does in some other tissues. Our purpose was to determine whether inhibition of type II 5α-reductase (via finasteride) alters red blood cell (RBC) production and serum markers of iron h...
متن کاملEffect of Thyroid Dysfunctions on Blood Cell Count and Red Blood Cell Indice
Abstract Background Thyroid hormones have a crucial role in metabolism and proliferation of blood cells. Thyroid dysfunction induces different effects on blood cells such as anemia, erythrocytosis leukopenia, thrombocytopenia, and in rare cases causes’ pancytopenia. It also alter RBC indices include MCV, MCH, MCHC and RDW. Thus this study attempted to evaluate effect of hypo & hyperthyroi...
متن کاملRED CELLS, IRON, AND ERYTHROPOIESIS Macrophages prevent human red blood cell reconstitution in immunodeficient mice
1Institute of Immunology, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, China; 2Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA; 3Columbia Center for Translational Immunology, Columbia University College of Physicians and Surgeons, New Yo...
متن کاملRed blood cell regeneration induced by subcutaneous recombinant erythropoietin: iron-deficient erythropoiesis in iron-replete subjects.
Limited red blood cell (RBC) regeneration often prevents collection of sufficient blood from autologous donors. We studied the effects of subcutaneous recombinant erythropoietin (rEPO) in subjects making frequent blood donations. Six healthy iron-replete male subjects took rEPO (200 U/kg) subcutaneously daily, and donated blood (450 mL) twice a week for 3 weeks. During a control study, these su...
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ژورنال
عنوان ژورنال: Blood
سال: 2013
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2012-09-454793